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Research Progress on Fluoride Solution Promoting the Survival of Replanted Teeth

Received: 4 March 2024     Accepted: 25 March 2024     Published: 17 April 2024
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Abstract

Tooth replantation is an operation in which the lost teeth due to various reasons are treated and replanted in the alveolar socket. The key lies in the regeneration of the alveolar blood vessels and the regeneration of the alveolar bone. Fluoride has been proved to be a substance that promotes the growth of bone cells and has been widely used worldwide. Fluorine is a rare element that mixes with bone minerals during the osteogenic phase. It is a known non hormonal factor that can affect bone formation and has a bidirectional regulatory effect on bone formation. Long term low doses can promote bone formation, while high doses can cause osteoporosis or osteosclerosis. Osteocalcin can regulate bone metabolism, maintain normal bone calcification, inhibit cartilage calcification and irregular crystal precipitation. The mechanism of action of fluoride is that fluoride can stimulate osteoblasts to secrete osteocalcin, allowing more hydroxyapatite crystals to combine with it and precipitate in the bone matrix. Therefore, an appropriate concentration of fluoride solution can promote bone remodeling of alveolar bone and dentin. Through the effect of fluorine on bone cells, fluoride can be applied to tooth replantation surgery in order to improve the success rate of surgery. It was found that fluoride can regulate bone formation by stimulating the proliferation and differentiation of immature osteoblasts, ultimately affecting tooth replantation.

Published in International Journal of Dental Medicine (Volume 10, Issue 1)
DOI 10.11648/j.ijdm.20241001.12
Page(s) 5-9
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Fluorine, Tooth Replantation, Dental Trauma

References
[1] Qian H. Risk factors and prevention strategies of traumatic dental injury in children [J]. J Dent Prev Treat, 2017, 25(8): 477-481.
[2] Moradi Majd N, Zohrehei H, Darvish A, et al. Continued root formation after delayed replantation of an avulsed immature permanent tooth [J]. Case Rep Dent, 2014, 2014: 832637.
[3] Zhao YH, Zhang M, Liu NX, et al. The combined use of cell sheet fragments of periodontal ligament stem cells and platelet-rich fibrin granules for avulsed tooth reimplantation [J]. Biomaterials, 2013, 34(22): 5506-5520.
[4] Najeeb S, Siddiqui F, Khurshid Z, et al. Effect of bisphosphonates on root resorption after tooth replantation—a systematic review [J]. Dent Traumatol, 2017, 33(2): 77-83.
[5] Zaleckiene V, Peciuliene V, Brukiene V, et al. Traumatic dental injuries: etiology, prevalence and possible outcomes [J]. Stomatologija, 2014, 16(1): 7-14.
[6] Jain N, Srilatha A, Doshi D, et al. Knowledge of emergency management of avulsed tooth among intern dental students: a questionnaire based study [J]. Int J Adolesc Med Health, 2018, 32(5).
[7] Priya MH, Tambakad PB, Naidu J. Pulp and Periodontal Regeneration of an Avulsed Permanent Mature Incisor Using Platelet-rich Plasma after Delayed Replantation: A 12-month Clinical Case Study [J]. J Endod, 2016, 42(1): 66-71.
[8] Fareley JR, Wergedal JE, Baylink DJ. Fluoride directly stimulates p ro liferation and alkaline phosphatase activity of boneforming cells [J]. Science, 1983, 22: 330-332.
[9] Duckworth RM, Lynch RJ. Fluoride Uptake to Demineralised Enamel: A Comparison of Sampling Techniques [J]. CariesRes, 1998, 32(6): 417-421.
[10] Bhawal UK, LeeHJ, Arikawa K, et al. Micromolar sodium fluoride mediates anti-osteoclastogenesis in porphyromonas gingivalis-induced alveolar bone loss [J]. Int J Oral Sci, 2015, 7(4): 242-249.
[11] Fang SS, Zhang LP, Liu L. Biological action of fluorine——fluorine action on bone [J]. Studies of Trace Elements and Health, 2011, 28(4): 62-64.
[12] Hua K. Department of Pathology. Institute of Endemie Disease. [J] Jilin University (medicine edition), 2004, 30(3): 345-347.
[13] Yan X. Shanxi Key Laboratory of Ecological Animal Science and Emironmental Melicine [J]. Arch Toxicol, 2009, 83(5): 451-458.
[14] Sun LT. Alteration of osteocaleis mRNA expression in avira outcoblants in dependence of sodium fhaoride and social-am selenite medium supplementation [J]. Acta Biologica Hungarics, 2010, 61(1): 23.
[15] Zhou YL, Shi HY, Li XN, et al. Role of endoplasmic reticulum stress in aberrant activation of fluoride-treated osteoblasts [J]. Biol Trace Elem Res, 2013, 154: 448-56.
[16] Bibby BG. A test of the effect of fluoride-containing dentifrices on dental caries [J]. J Dent Res, 1945, 24: 297-303.
[17] Choubisa SL, Choubisa L, Choubisa DK. Endemic fluorosis in Rajasthan [J]. Indian J Environ Health, 2001, 43: 177-189.
[18] Qiu YF, Tang Y, Shen YF, et al. Effect of fluoride exposure on the proliferation and osteogenic differentiation of human periodontal membrane stem cells [J]. Journal of Stomato logical Research, 2019, 36(9): 866-870.
[19] Liu Y, Zheng Y, Ding G, et al. Periodontal Ligament Stem Cell-mediated treatment for periodontitis in miniature swine [J]. Stem Cells, 2008, 26(4): 1065-1073.
[20] Gronthos S, Brahim J, Li W, et al. Stem cell properties of human dental pulp stem cells [J]. J Dent Res, 2002, 81(8): 531-535.
[21] Chadwick BL, Roy J, Knox J, et al. The effect of topical fluorides on decalcification in patients with fixed orthodontic appliances: a systematic review [J]. Am J Orthod Dentofacial Orthop, 2005, 128(5): 601-606.
Cite This Article
  • APA Style

    Yang, H., Lin, W., Guo, J., Luo, Y., Hu, H., et al. (2024). Research Progress on Fluoride Solution Promoting the Survival of Replanted Teeth. International Journal of Dental Medicine, 10(1), 5-9. https://doi.org/10.11648/j.ijdm.20241001.12

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    ACS Style

    Yang, H.; Lin, W.; Guo, J.; Luo, Y.; Hu, H., et al. Research Progress on Fluoride Solution Promoting the Survival of Replanted Teeth. Int. J. Dent. Med. 2024, 10(1), 5-9. doi: 10.11648/j.ijdm.20241001.12

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    AMA Style

    Yang H, Lin W, Guo J, Luo Y, Hu H, et al. Research Progress on Fluoride Solution Promoting the Survival of Replanted Teeth. Int J Dent Med. 2024;10(1):5-9. doi: 10.11648/j.ijdm.20241001.12

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  • @article{10.11648/j.ijdm.20241001.12,
      author = {Hui-Qin Yang and Wan-Yun Lin and Jun-Ling Guo and Ying-Yu Luo and Hui-Juan Hu and Minhaj Ahmad and Zhu-Ling Guo},
      title = {Research Progress on Fluoride Solution Promoting the Survival of Replanted Teeth
    },
      journal = {International Journal of Dental Medicine},
      volume = {10},
      number = {1},
      pages = {5-9},
      doi = {10.11648/j.ijdm.20241001.12},
      url = {https://doi.org/10.11648/j.ijdm.20241001.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdm.20241001.12},
      abstract = {Tooth replantation is an operation in which the lost teeth due to various reasons are treated and replanted in the alveolar socket. The key lies in the regeneration of the alveolar blood vessels and the regeneration of the alveolar bone. Fluoride has been proved to be a substance that promotes the growth of bone cells and has been widely used worldwide. Fluorine is a rare element that mixes with bone minerals during the osteogenic phase. It is a known non hormonal factor that can affect bone formation and has a bidirectional regulatory effect on bone formation. Long term low doses can promote bone formation, while high doses can cause osteoporosis or osteosclerosis. Osteocalcin can regulate bone metabolism, maintain normal bone calcification, inhibit cartilage calcification and irregular crystal precipitation. The mechanism of action of fluoride is that fluoride can stimulate osteoblasts to secrete osteocalcin, allowing more hydroxyapatite crystals to combine with it and precipitate in the bone matrix. Therefore, an appropriate concentration of fluoride solution can promote bone remodeling of alveolar bone and dentin. Through the effect of fluorine on bone cells, fluoride can be applied to tooth replantation surgery in order to improve the success rate of surgery. It was found that fluoride can regulate bone formation by stimulating the proliferation and differentiation of immature osteoblasts, ultimately affecting tooth replantation.
    },
     year = {2024}
    }
    

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  • TY  - JOUR
    T1  - Research Progress on Fluoride Solution Promoting the Survival of Replanted Teeth
    
    AU  - Hui-Qin Yang
    AU  - Wan-Yun Lin
    AU  - Jun-Ling Guo
    AU  - Ying-Yu Luo
    AU  - Hui-Juan Hu
    AU  - Minhaj Ahmad
    AU  - Zhu-Ling Guo
    Y1  - 2024/04/17
    PY  - 2024
    N1  - https://doi.org/10.11648/j.ijdm.20241001.12
    DO  - 10.11648/j.ijdm.20241001.12
    T2  - International Journal of Dental Medicine
    JF  - International Journal of Dental Medicine
    JO  - International Journal of Dental Medicine
    SP  - 5
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2472-1387
    UR  - https://doi.org/10.11648/j.ijdm.20241001.12
    AB  - Tooth replantation is an operation in which the lost teeth due to various reasons are treated and replanted in the alveolar socket. The key lies in the regeneration of the alveolar blood vessels and the regeneration of the alveolar bone. Fluoride has been proved to be a substance that promotes the growth of bone cells and has been widely used worldwide. Fluorine is a rare element that mixes with bone minerals during the osteogenic phase. It is a known non hormonal factor that can affect bone formation and has a bidirectional regulatory effect on bone formation. Long term low doses can promote bone formation, while high doses can cause osteoporosis or osteosclerosis. Osteocalcin can regulate bone metabolism, maintain normal bone calcification, inhibit cartilage calcification and irregular crystal precipitation. The mechanism of action of fluoride is that fluoride can stimulate osteoblasts to secrete osteocalcin, allowing more hydroxyapatite crystals to combine with it and precipitate in the bone matrix. Therefore, an appropriate concentration of fluoride solution can promote bone remodeling of alveolar bone and dentin. Through the effect of fluorine on bone cells, fluoride can be applied to tooth replantation surgery in order to improve the success rate of surgery. It was found that fluoride can regulate bone formation by stimulating the proliferation and differentiation of immature osteoblasts, ultimately affecting tooth replantation.
    
    VL  - 10
    IS  - 1
    ER  - 

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Author Information
  • School of Dentistry, Hainan Medical University, Haikou, China

  • School of Dentistry, Hainan Medical University, Haikou, China

  • School of Dentistry, Hainan Medical University, Haikou, China

  • School of Dentistry, Hainan Medical University, Haikou, China

  • School of Dentistry, Hainan Medical University, Haikou, China

  • School of International Education, Hainan Medical University, Haikou, China

  • School of Dentistry, Hainan Medical University, Haikou, China; Department of Health Management Center, The First Affiliated Hospital of Hainan Medical University, Haikou, China

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